Search | Engineering

Subscribe Submit

Home Journals Focus Achievement Fronts About Us 中文版

Resource Type

Journal Article 573

Conference Videos 12

Conference Information 1

Year

2024 1

2023 44

2022 49

2021 61

2020 30

2019 60

2018 36

2017 34

2016 29

2015 31

2014 27

2013 30

2012 25

2011 27

2010 17

2009 27

2008 10

2007 15

2006 2

2005 2

open ︾

Keywords

cancer 27

lung cancer 16

fuel cell 13

immunotherapy 12

breast cancer 8

cervical cancer 8

cancer therapy 7

targeted therapy 7

solar cell 6

Cancer 5

hematopoietic stem cell transplantation 5

hydrogen energy 5

prognosis 5

stem cell 5

Colorectal cancer 4

cell proliferation 4

chemotherapy 4

control 4

immune checkpoint inhibitor 4

open ︾

Search scope:

排序： Display mode:

Identification of cancer stem cells provides novel tumor models for drug discovery

Douglas D. Fang, Danyi Wen, Yajun Xu

Frontiers of Medicine 2012, Volume 6, Issue 2, Pages 112-121 doi: 10.1007/s11684-012-0199-1

Abstract:

Cancer stem cells (CSCs) have received considerable attention from the research community since theybecoming increasingly important for eradicating CSCs in heterogeneous tumor masses and to cure the cancer

Keywords： cancer stem cell tumor model drug discovery

HTML PDF Collect

Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-likecells enriched with tumor spheroids from a non-small cell lung cancer cell line

Douglas D. Fang, Joan Cao, Jitesh P. Jani, Konstantinos Tsaparikos, Alessandra Blasina, Jill Kornmann, Maruja E. Lira, Jianying Wang, Zuzana Jirout, Justin Bingham, Zhou Zhu, Yin Gu, Gerrit Los, Zdenek Hostomsky, Todd VanArsdale

Frontiers of Medicine 2013, Volume 7, Issue 4, Pages 462-476 doi: 10.1007/s11684-013-0270-6

Abstract: become crucial for developing more effective therapies that target highly tumorigenic and drug-resistant cancerstem cell (CSC) populations.In this study, we demonstrate that a subset of cancer cells with CSC properties may be enriched intotumor spheroids under stem cell conditions from a non-small cell lung cancer cell line.00477736 enhances the anti-proliferative effect of gemcitabine against both the parental and the CSC-like cell

Keywords： drug resistance cancer stem cell checkpoint kinase 1 (CHK1) PF-00477736 lung cancer tumorigenicity

HTML PDF Collect

Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 361-373 doi: 10.1007/s11684-018-0656-6

Abstract:

The cell-biological program termed the epithelial-to-mesenchymal transition (EMT) plays an importantrole in both development and cancer progression.Depending on the contextual signals and intracellular gene circuits of a particular cell, this programThese cell states display distinctive cellular characteristics, including stemness, invasiveness, drug-resistanceand the ability to form metastases at distant organs, and thereby contribute to cancer metastasis and

Keywords： epithelial-to-mesenchymal transition cancer metastasis cancer stem cell

HTML PDF Collect

The unregulated commercialization of stem cell treatments: a global perspective

Douglas Sipp

Frontiers of Medicine 2011, Volume 5, Issue 4, Pages 348-355 doi: 10.1007/s11684-011-0150-x

Abstract: Research into the biological properties and clinical potential of stem cells has spurred strong publicof demonstrated safety and efficacy have been developed with the exception of uses of hematopoietic stembasis notwithstanding, hundreds of companies and private clinics around the world now sell putative stemcell treatments for an enormously broad range of medical and quality-of-life conditions.In this review, I provide an overview of the global industry in pseudomedical stem cell treatments, with

Keywords： stem cell tourism medical ethics stem cell policy and regulation alternative medicine

HTML PDF Collect

The regulatory sciences for stem cell-based medicinal products

Bao-Zhu Yuan,Junzhi Wang

Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 190-200 doi: 10.1007/s11684-014-0323-5

Abstract:

Over the past few years, several new achievements have been made from stem cell studies, many of whichMoreover, some stem cell-based products have been approved for marketing by different national regulatoryHowever, many critical issues associated mainly with incomplete understanding of stem cell biology andcell regulatory sciences with a goal of promoting the steadfast growth of the well-regulated stem celltherapies abreast of evolvement of stem cell sciences and technologies.

Keywords： stem cell-based medicinal products (SCMPs) stem cell therapy (SCT) safety effectiveness standards guidelines

HTML PDF Collect

Therapeutic potential of stem cell in liver regeneration

Jinzheng LI, Min LI, Bolin NIU, Jianping GONG

Frontiers of Medicine 2011, Volume 5, Issue 1, Pages 26-32 doi: 10.1007/s11684-011-0107-0

Abstract: Stem cell therapy, with the ability for self-renewal and potential for multilineage differentiation,cells derived from multipotent stem cells leads to donor cell-mediated repopulation of the liver andHowever, a registered clinical application based on stem cell technology will take at least an additional5 to 10 years because of some limitations; e.g. the lack of suitable cell sources and risk of teratomaThis review summarizes the general understanding of the therapeutic potentials of stem cells in liver

Keywords： stem cell liver disease regenerative medicine

HTML PDF Collect

Stem cell niches and endogenous electric fields in tissue repair

Li LI, Jianxin JIANG

Frontiers of Medicine 2011, Volume 5, Issue 1, Pages 40-44 doi: 10.1007/s11684-011-0108-z

Abstract:

Adult stem cells are responsible for homeostasis and repair of many tissues.Endogenous adult stem cells reside in certain regions of organs, known as the stem cell niche, whichMany regulatory factors are involved in the stem cell-based repair process, including stem cell nichesHere we briefly review the role of stem cell niches and endogenous electric fields in tissue repair,and hypothesize that endogenous electric fields become part of stem cell niche in the wound site.

Keywords： stem cell stem cell niche electric field tissue repair

HTML PDF Collect

Transcriptomics and proteomics in stem cell research

Hai Wang,Qian Zhang,Xiangdong Fang

Frontiers of Medicine 2014, Volume 8, Issue 4, Pages 433-444 doi: 10.1007/s11684-014-0336-0

Abstract:

Stem cells are capable of self-renewal and differentiation, and the processes regulating these eventsIn particular, the molecular mechanisms of the self-renewal, proliferation, and differentiation of stemcell biology.and proteomic characterization of the different stem cell processes.cell biology and promote the clinical applications of stem cells.

Keywords： embryonic stem cells transcriptomics proteomics

HTML PDF Collect

Advancement of human leukocyte antigen-partially matched related hematopoietic stem cell transplantation

Xiaodong Mo, Xiaojun Huang

Frontiers of Medicine 2013, Volume 7, Issue 3, Pages 306-315 doi: 10.1007/s11684-013-0279-x

Abstract:

Allogeneic hematopoietic stem cell transplantation (HSCT) is one of the most effective options forSeveral protocols (with or without ex vivo T-cell depletion (TCD)) have been established worldwide

Keywords： partially matched related donor hematopoietic stem cell transplantation allogeneic

HTML PDF Collect

Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation

Frontiers of Medicine 2022, Volume 16, Issue 2, Pages 227-239 doi: 10.1007/s11684-021-0896-8

Abstract: Chronic stress impairs radial neural stem cell (rNSC) differentiation and adult hippocampal neurogenesis

Keywords： cannabidiol depression radial neural stem cells neurogenesis

HTML PDF Collect

In vivo imaging of hematopoietic stem cell development in the zebrafish

Panpan Zhang, Feng Liu

Frontiers of Medicine 2011, Volume 5, Issue 3, Pages 239-247 doi: 10.1007/s11684-011-0123-0

Abstract: imaging is crucial for developmental biology and can further help to follow cell development/differentiationhas facilitated tracing of the developmental dynamics of a specific organ, tissue, or even a single cellhematopoiesis due to its transparent embryo at early stage; moreover, different zebrafish hematopoietic stem

Keywords： hematopoietic stem cell hematopoiesis in vivo imaging transgenics zebrafish

HTML PDF Collect

Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property

Yuting Tan,Han Liu,Saijuan Chen

Frontiers of Medicine 2015, Volume 9, Issue 4, Pages 412-420 doi: 10.1007/s11684-015-0423-x

Abstract: mutations provides the first proof-of-principle investigation on the identification of preleukemic stemAlthough DNMT3A mutations alone may only transform hematopoietic stem cells into pre-LSCs without causing

Keywords： preleukemic stem cell acute myeloid leukemia relapse DNMT3A

HTML PDF Collect

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancercell proliferation and

Frontiers of Medicine 2021, Volume 15, Issue 6, Pages 942-942 doi: 10.1007/s11684-021-0876-z

HTML PDF Collect

Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity

Chuanfeng Wu, Cynthia E. Dunbar

Frontiers of Medicine 2011, Volume 5, Issue 4, Pages 356-371 doi: 10.1007/s11684-011-0159-1

Abstract: Virus-based vectors are widely used in hematopoietic stem cell (HSC) gene therapy, and have the abilityreview will summarize current information on the mechanisms of insertional mutagenesis in hematopoietic stem

Keywords： gene therapy hematopoietic stem cells insertional mutagenesis genotoxicity induced pluripotent stem cell

HTML PDF Collect

The stem cell and tissue engineering research in Chinese ophthalmology

GE Jian, LIU Jingbo

Frontiers of Medicine 2007, Volume 1, Issue 1, Pages 6-10 doi: 10.1007/s11684-007-0002-x

Abstract: Much has been considerably developed recently in the ophthalmic research of stem cell (SC) and tissue

Keywords： available observable neuroregeneration protection function reconstruction

HTML PDF Collect

Title Author Date Type Operation

Identification of cancer stem cells provides novel tumor models for drug discovery

Douglas D. Fang, Danyi Wen, Yajun Xu

Journal Article

Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-likecells enriched with tumor spheroids from a non-small cell lung cancer cell line

Journal Article

Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

Journal Article

The unregulated commercialization of stem cell treatments: a global perspective

Douglas Sipp

Journal Article

The regulatory sciences for stem cell-based medicinal products

Bao-Zhu Yuan,Junzhi Wang

Journal Article

Therapeutic potential of stem cell in liver regeneration

Jinzheng LI, Min LI, Bolin NIU, Jianping GONG